منابع مشابه
Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
Helicases are specialized molecular motors that separate duplex nucleic acids into single strands. The RecQ family of helicases functions at the interface of DNA replication, recombination and repair in bacterial and eukaryotic cells. They are key, multifunctional enzymes that have been linked to three human diseases: Bloom's, Werner's and Rothmund-Thomson's syndromes. This review summarizes re...
متن کاملPreparing to unwind
A combination of protein crystallography and biochemistry has revealed how a ring-shaped helicase might trap a single DNA strand as the double helix melts, and before it is unwound.
متن کاملTactical Unwind ?
Political developments in Britain since 2001 provide reason to believe that the nature of tactical voting at the 2005 general election may have been different in character from that in other recent elections. This paper examines the changes in party preference structure and finds no sign of greater distance between Labour and the Liberal Democrats. Instead the most notable change is a collapse ...
متن کاملPutting Two Heads Together to Unwind DNA
The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2-7 replicative helicase encircles double-stranded DNA as head-to-head double hexamers.
متن کاملGenome stability: Failure to unwind causes cancer
Several rare human genetic diseases are characterized at the cellular level by a high incidence of chromosomal rearrangements. Some of these disorders — in particular, xeroderma pigmentosum — are associated with abnormalities in the repair of DNA damage, whereas others — notably Fanconi’s anaemia and Bloom’s syndrome — are not. Rapid progress has been made in recent years in the characterisatio...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2011
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2011.03.001